Ohmi T, Mue S, Tamura G, Ishihara T, Hoshi S, Takishima T
Tohoku J Exp Med. 1983 Aug;140(4):421-8. doi: 10.1620/tjem.140.421.
Using the skin of monkeys, we studied the participation of histamine receptors in the immediate skin reaction. Intradermal injection of H2 agonist produced whealing reaction to a significant degree, although this effect was not so remarkable as the effect of H1 agonist. A non-thiourea H2 antagonist showed a significant inhibitory effect on the whealing reaction to allergen, compound 48/80, and histamine. These results suggest that H2 antagonist prevented the whealing reaction by changing the vascular reaction to secreted or exogenous histamine. However, the participation of histamine receptors on dermal mast cells in the immediate skin allergic reaction is still left inconclusive.
我们利用猴的皮肤研究了组胺受体在皮肤即刻反应中的作用。皮内注射H2激动剂可产生显著程度的风团反应，尽管这种效应不如H1激动剂的效应显著。一种非硫脲类H2拮抗剂对变应原、化合物48/80和组胺引起的风团反应显示出显著的抑制作用。这些结果表明，H2拮抗剂通过改变对分泌或外源性组胺的血管反应来预防风团反应。然而，组胺受体在皮肤即刻过敏反应中真皮肥大细胞上的作用仍无定论。
