Department of Organic Chemistry, Stockholm University , SE-106 91 Stockholm, Sweden.
Stockholm Brain Institute, Karolinska Institutet , SE-171 77 Stockholm, Sweden.
Org Lett. 2017 Sep 1;19(17):4548-4551. doi: 10.1021/acs.orglett.7b02139. Epub 2017 Aug 17.
A new Rh-catalyzed, three-component reaction for the oxytrifluoromethylthiolation of α-diazoketones was developed. The SCF functionality was introduced using a stable dibenzenesulfonimide reagent under mild conditions. Alcohols, acetals, and ethers were used as the alkoxy sources. Cyclic ethers underwent a trifunctionalization reaction through the introduction of SCF, OR, and N(SOPh) substituents in a single step.
开发了一种新的 Rh 催化的、三组分反应，用于α-重氮酮的氧三氟甲硫基化反应。在温和的条件下，使用稳定的二苯磺酰亚胺试剂引入 SCF 官能团。醇、缩醛和醚可用作烷氧基源。环醚通过在单一步骤中引入 SCF、OR 和 N(SOPh)取代基，经历了三官能化反应。
