Choi D W
Brain Res. 1987 Feb 17;403(2):333-6. doi: 10.1016/0006-8993(87)90070-9.
The dextrorotatory morphinan opioid, dextrorphan, which has recently been reported to block the excitation of cortical neurons by N-methyl-D-aspartate, was found at 10-100 microM concentrations to attenuate both morphological and chemical evidence of glutamate neurotoxicity in murine neocortical cell cultures; a similar effect was found with its methyl ester derivative, dextromethorphan. Given other data suggesting that glutamate neurotoxicity may participate in the pathogenesis of the central neuronal loss associated with certain human neurological diseases, the present observations raise the possibility that these clinically tested opioids, or related compounds, may eventually prove to have some clinical therapeutic utility.
右旋吗啡喃类阿片样物质右啡烷，最近有报道称其可阻断N-甲基-D-天冬氨酸对皮质神经元的兴奋作用，发现在10 - 100微摩尔浓度时，可减轻小鼠新皮质细胞培养物中谷氨酸神经毒性的形态学和化学证据；其甲酯衍生物右美沙芬也有类似作用。鉴于其他数据表明谷氨酸神经毒性可能参与某些人类神经疾病相关的中枢神经元丢失的发病机制，目前的观察结果提示，这些经过临床测试的阿片类药物或相关化合物最终可能证明具有一定的临床治疗效用。
