Monyer H, Choi D W
Department of Neurology, Stanford University Medical Center, CA 94305.
Brain Res. 1988 Apr 12;446(1):144-8. doi: 10.1016/0006-8993(88)91304-2.
The non-narcotic dextrorotatory morphinan, dextrorphan, as well as its levorotatory opioid enantiomer, levorphanol, and its O-methyl derivative, dextromethorphan, have recently been shown to antagonize N-methyl-D-aspartate receptor-mediated neurotoxicity. Consistent with in vivo data suggesting that this neurotoxicity contributes to the neuronal damage associated with hypoglycemia, micromolar concentrations of these morphinans markedly attenuated the injury of cultured mouse cortical neurons produced by acute glucose deprivation. These observations lend specific support to the possibility that morphinan compounds may prove to have clinical therapeutic utility in hypoglycemic encephalopathy.
非麻醉性右旋吗啡喃、右啡烷，以及其左旋阿片类对映体、左啡诺及其O-甲基衍生物右美沙芬，最近已被证明可拮抗N-甲基-D-天冬氨酸受体介导的神经毒性。体内数据表明这种神经毒性会导致与低血糖相关的神经元损伤，与此一致的是，这些吗啡喃的微摩尔浓度可显著减轻急性葡萄糖剥夺对培养的小鼠皮层神经元造成的损伤。这些观察结果为吗啡喃化合物可能在低血糖性脑病中具有临床治疗效用这一可能性提供了具体支持。
