水合作用提高交联透明质酸纳米颗粒内钆-DTPA 的弛豫率。
Hydrodenticity to enhance relaxivity of gadolinium-DTPA within crosslinked hyaluronic acid nanoparticles.
机构信息
Department of Chemical, Materials & Production Engineering, University of Naples Federico II, Piazzale V. Tecchio 80, 80125 Naples, Italy.
Center for Advanced Biomaterials for Healthcare IIT@CRIB, Istituto Italiano di Tecnologia (IIT), Largo Barsanti e Matteucci 53, 80125 Naples, Italy.
出版信息
Nanomedicine (Lond). 2017 Sep;12(18):2199-2210. doi: 10.2217/nnm-2017-0098. Epub 2017 Aug 17.
AIM
The efficacy of gadolinium (Gd) chelates as contrast agents for magnetic resonance imaging remains limited owing to poor relaxivity and toxic effects. Here, the effect of the hydration of the hydrogel structure on the relaxometric properties of Gd-DTPA is explained for the first time and called Hydrodenticity.
RESULTS
The ability to tune the hydrogel structure is proved through a microfluidic flow-focusing approach able to produce crosslinked hyaluronic acid nanoparticles, analyzed regarding the crosslink density and mesh size, and connected to the characteristic correlation times of the Gd-DTPA.
CONCLUSION
Hydrodenticity explains the boosting (12-times) of the Gd-DTPA relaxivity by tuning hydrogel structural parameters, potentially enabling the reduction of the administration dosage as approved for clinical use. [Formula: see text].
目的
由于弛豫率差和毒性作用，镧系元素（Gd）螯合物作为磁共振成像对比剂的效果仍然有限。在这里，首次解释了水凝胶结构的水合作用对 Gd-DTPA 弛豫性质的影响，并将其称为水合作用。
结果
通过微流控流聚焦方法证明了调节水凝胶结构的能力，该方法能够生产交联透明质酸纳米颗粒，并对其交联密度和网格尺寸进行分析，并与 Gd-DTPA 的特征相关时间相关联。
结论
水合作用解释了通过调节水凝胶结构参数（提高 12 倍）来提高 Gd-DTPA 的弛豫率，这可能使给药剂量得以减少，从而获得临床应用的批准。
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