Tulp O L, Jones C T
Comp Biochem Physiol A Comp Physiol. 1987;86(1):67-72. doi: 10.1016/0300-9629(87)90278-7.
Groups of lean or pre-obese LA/N-cp rats were subjected to a program of vigorous exercise (less than 4 hr/day) or remained sedentary from 6 weeks until 12 weeks of age. Sedentary pre-obese rats gained weight twice as rapidly as sedentary lean rats. Exercise treatment resulted in greater decrements in body wt in obese than in lean rats, but did not result in absolute weight loss in either group. At 12 weeks of age, fat pad weights in principle depots were 10-15 times greater in corpulent than in lean rats and were significantly smaller in the exercised groups of both phenotypes, and corresponded with lower relative adiposity compared to corresponding sedentary groups. Heart weights were greater in corpulent than lean, while gastrocnemius muscle weights were similar in both phenotypes. Exercise was without effect on the weight of either muscle tissue in either phenotype. Interscapular brown adipose tissue weights and the IBAT:BW ratio were greater in obese than in lean rats. IBAT weights were lower in exercised than sedentary rats of either phenotype, but the IBAT:BW ratio was lower only in the obese exercised rats. In sedentary rats, L-alpha-glycerophosphate dehydrogenase and malic enzyme activity were greater in obese than lean, and exercise treatment resulted in increased L-alpha-glycerophosphate dehydrogenase and malic enzyme only in lean rats. These results are consistent with a redistribution of energy expenditure from energy storing to energy dissipating pathways following vigorous exercise, resulting in slowed rates of weight gain and body fat accretion in both lean and obese animals, with the most significant decrements among pre-obese rats.
将瘦型或肥胖前期的LA/N-cp大鼠分为两组，一组进行剧烈运动（每天运动时间少于4小时），另一组从6周龄至12周龄保持 sedentary 状态。 sedentary 的肥胖前期大鼠体重增加速度是 sedentary 的瘦型大鼠的两倍。运动处理使肥胖大鼠的体重下降幅度大于瘦型大鼠，但两组均未出现绝对体重减轻。在12周龄时，肥胖大鼠主要脂肪垫的重量比瘦型大鼠大10 - 15倍，且两种表型的运动组脂肪垫重量均显著较小，与相应的 sedentary 组相比，相对肥胖程度较低。肥胖大鼠的心脏重量大于瘦型大鼠，而两种表型的腓肠肌重量相似。运动对两种表型的任何一种肌肉组织重量均无影响。肥胖大鼠的肩胛间棕色脂肪组织重量和IBAT:BW比值均高于瘦型大鼠。两种表型的运动大鼠的IBAT重量均低于 sedentary 大鼠，但仅肥胖运动大鼠的IBAT:BW比值较低。在 sedentary 大鼠中，肥胖大鼠的L-α-甘油磷酸脱氢酶和苹果酸酶活性高于瘦型大鼠，运动处理仅使瘦型大鼠的L-α-甘油磷酸脱氢酶和苹果酸酶活性增加。这些结果与剧烈运动后能量消耗从能量储存途径重新分配到能量消散途径一致，导致瘦型和肥胖动物的体重增加和体脂积累速度减慢，肥胖前期大鼠的下降最为显著。
