Tulp O L, McKee S T
Biochem Biophys Res Commun. 1986 Oct 15;140(1):134-42. doi: 10.1016/0006-291x(86)91068-5.
Pre-obese LA/N-cp rats consumed more food and gained weight more rapidly than their lean littermates, and measures of adipose tissue depots indicated that the excess weight was deposited principally as carcass fat. Serum T3 concentrations and resting metabolic rates were lower in corpulent than in lean animals, consistent with a greater efficiency of weight gain in those animals. In vitro measures of T3 neogenesis from T4 were lower in corpulent than in lean animals in liver, kidney, and skeletal muscle and greater in interscapular brown adipose tissue. The intracellular generation of T3 from T4 is a fundamental component of the normal adaptive response to alterations in diet and environment, and is an essential prerequisite for the expression of non-shivering thermogenesis. These results are consistent with a functional impairment in the activity of the enzyme T4-5'-deiodinase in peripheral tissues, and suggest that this impairment is contributory if not causative of obesity in this strain of rat.
肥胖前期的LA/N-cp大鼠比其瘦的同窝仔鼠摄入更多食物，体重增加更快，脂肪组织储存量的测量表明，多余的体重主要以体脂形式储存。肥胖动物的血清T3浓度和静息代谢率低于瘦动物，这与这些动物更高的体重增加效率一致。在肝脏、肾脏和骨骼肌中，肥胖动物由T4生成T3的体外测量值低于瘦动物，而在肩胛间棕色脂肪组织中则更高。由T4在细胞内生成T3是对饮食和环境变化的正常适应性反应的一个基本组成部分，也是无颤抖产热表达的必要前提。这些结果与外周组织中T4-5'-脱碘酶活性的功能受损一致，并表明这种损伤即使不是该品系大鼠肥胖的原因，也是促成因素。
