缺氧诱导的乌龟心脏代谢改变。海绵状心肌与致密心肌的比较。

Metabolic alterations induced by hypoxia in the tortoise heart. Comparison between spongy and compact myocardium.

作者信息

Martin D, Grably S, Royer F, Benchetrit G, Rossi A, Tota B, Marciano V, Farina F, Zummo G

出版信息

Comp Biochem Physiol A Comp Physiol. 1987;86(2):319-23. doi: 10.1016/0300-9629(87)90337-9.

Abstract

Experiments were performed to check the tolerance to severe hypoxia of the tissue layers (compact and spongy) of the tortoise heart. The animals were subjected to hypoxia (7% O2) at 18 degrees C, 28 degrees C and 38 degrees C for 30, 6 and 2 hr respectively, or to anoxia for 30 hr at 18 degrees C and 2 hr at 38 degrees C. At 18 degrees C the metabolic alterations caused by a 30 hr hypoxia were mild whereas at 28 degrees C and 38 degrees C the cardiac glycogen was depleted, lactate had accumulated and the phosphate creatine and ATP content had decreased. The extent of these metabolic changes was similar in the compact and in the spongy layers of the heart.

摘要

进行了实验以检测乌龟心脏组织层（致密层和海绵层）对严重缺氧的耐受性。将动物分别在18℃、28℃和38℃下暴露于缺氧环境（7%氧气）中30小时、6小时和2小时，或在18℃下进行30小时缺氧处理，在38℃下进行2小时缺氧处理。在18℃时，30小时缺氧引起的代谢变化较轻，而在28℃和38℃时，心脏糖原耗竭，乳酸积累，磷酸肌酸和三磷酸腺苷（ATP）含量下降。这些代谢变化的程度在心脏的致密层和海绵层中相似。