Isobe Yoshihiro, Kosaka Toru, Kuwahara Go, Mikami Hiroshi, Saku Taro, Kodama Shohta
Atree Inc., 16-12-1 Hiroo Shibuya-ku, Tokyo, 150-0012, Japan.
Department of Regenerative Medicine & Transplantation, Faculty of Medicine, Fukuoka University, 7-45-1, Nanakuma, Jonan-ku, Fukuoka City, Fukuoka Pref, 814-0133, Japan.
Materials (Basel). 2012 Mar 16;5(3):501-511. doi: 10.3390/ma5030501.
Oriented collagen scaffolds were developed in the form of sheet, mesh and tube by arraying flow-oriented collagen string gels and dehydrating the arrayed gels. The developed collagen scaffolds can be any practical size with any direction of orientation for tissue engineering applications. The birefringence of the collagen scaffolds was quantitatively analyzed by parallel Nicols method. Since native collagen in the human body has orientations such as bone, cartilage, tendon and cornea, and the orientation has a special role for the function of human organs, the developed various types of three-dimensional oriented collagen scaffolds are expected to be useful biomaterials for tissue engineering and regenerative medicines.
通过排列流动取向的胶原串凝胶并使排列后的凝胶脱水，制备出片状、网状和管状的取向胶原支架。所制备的胶原支架可为任何实际尺寸，且具有任何取向方向，用于组织工程应用。采用平行尼科耳棱镜法对胶原支架的双折射进行了定量分析。由于人体中的天然胶原具有如骨骼、软骨、肌腱和角膜等的取向，且该取向对人体器官的功能具有特殊作用，因此所制备的各种类型的三维取向胶原支架有望成为组织工程和再生医学的有用生物材料。
