Newell Marnie, Baker Kristi, Postovit Lynne M, Field Catherine J
Department of Agricultural Food and Nutritional Science, Faculty of Agricultural, Life and Environmental Sciences, 4-126 Li Ka Shing Center for Health Research Innovation, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Department of Oncology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Int J Mol Sci. 2017 Aug 17;18(8):1784. doi: 10.3390/ijms18081784.
Globally, there were 14.1 million new cancer diagnoses and 8.2 million cancer deaths in 2012. For many cancers, conventional therapies are limited in their successes and an improved understanding of disease progression is needed in conjunction with exploration of alternative therapies. The long chain polyunsaturated fatty acid, docosahexaenoic acid (DHA), has been shown to enhance many cellular responses that reduce cancer cell viability and decrease proliferation both in vitro and in vivo. A small number of studies suggest that DHA improves chemotherapy outcomes in cancer patients. It is readily incorporated into cancer cell membranes and, as a result there has been considerable research regarding cell membrane initiated events. For example, DHA has been shown to mediate the induction of apoptosis/reduction of proliferation in vitro and in vivo. However, there is limited research into the effect of DHA on cell cycle regulation in cancer cells and the mechanism(s) by which DHA acts are not fully understood. The purpose of the current review is to provide a critical examination of the literature investigating the ability of DHA to stall progression during different cell cycle phases in cancer cells, as well as the consequences that these changes may have on tumour growth, independently and in conjunction with chemotherapy.
2012年，全球有1410万例新发癌症诊断病例和820万例癌症死亡病例。对于许多癌症来说，传统疗法的成效有限，需要在探索替代疗法的同时，更好地了解疾病进展情况。长链多不饱和脂肪酸二十二碳六烯酸（DHA）已被证明能增强多种细胞反应，在体外和体内均可降低癌细胞活力并减少增殖。少数研究表明，DHA可改善癌症患者的化疗效果。它很容易融入癌细胞膜，因此，关于细胞膜引发的事件已有大量研究。例如，DHA已被证明在体外和体内均可介导细胞凋亡的诱导/增殖的减少。然而，关于DHA对癌细胞细胞周期调控的影响的研究有限，且DHA的作用机制尚未完全明确。本综述的目的是对相关文献进行批判性审视，这些文献研究了DHA在癌细胞不同细胞周期阶段阻止进展的能力，以及这些变化单独或与化疗联合时可能对肿瘤生长产生的影响。
