别嘌醇对乙醇喂养的小火鸡心脏保护作用的评估。
Evaluation of allopurinol as a cardioprotectant in ethanol-fed turkey poults.
作者信息
Czarnecki C M, McVey A S, Olivero D K
出版信息
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;86(1):67-71. doi: 10.1016/0742-8413(87)90146-0.
Cardioprotectant effects of allopurinol were investigated in ethanol-fed poults during induction of cardiomyopathy and during a period of ethanol abstinence. In young poults fed ethanol, allopurinol has an additive effect on depression of growth but has little or no effect on caloric consumption. Allopurinol significantly depresses heart weight and heart weight to body weight ratios in young poults. In poults 5 weeks and older, allopurinol depresses significantly body weight and caloric consumption. Although allopurinol depresses heart weight in older poults, it appears to have little or no effect on heart weight to body weight ratios. Cardioprotective effect of allopurinol is more apparent during the inductive process than during the recovery phase.
在诱导心肌病期间以及戒酒期间，研究了别嘌呤醇对用乙醇喂养的雏鸡的心脏保护作用。在用乙醇喂养的幼雏中，别嘌呤醇对生长抑制有相加作用，但对热量消耗几乎没有影响或没有影响。别嘌呤醇显著降低幼雏的心脏重量以及心脏重量与体重的比值。在5周及以上的雏鸡中，别嘌呤醇显著降低体重和热量消耗。虽然别嘌呤醇降低了老龄雏鸡的心脏重量，但它对心脏重量与体重的比值似乎几乎没有影响或没有影响。别嘌呤醇的心脏保护作用在诱导过程中比在恢复阶段更明显。
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