Swartz T A, Roumiantzeff M, Peyron L, Stopler T, Drucker J, Epstein I, Leitner L, Goldblum N
Dev Biol Stand. 1986;65:159-66.
A five-year serologic follow-up and a four-year monitoring of the polio and pertussis morbidity in an area immunized with a 2 + 1 dose schedule of a combined DTP-Po vaccine have shown that: the individual protection against polio measured by the presence of neutralizing antibody persists at a very adequate level five years after the first booster; after three years of a steady high proportion of children with pertussis antibody, a considerable drop is observed and in about 28% of individuals agglutinin levels of less than 1:20 were found five years after booster; the community protection against paralytic poliomyelitis and pertussis is satisfactory up to four years after the introduction of the program. Continuation of immunization with a 2 + 1 dose schedule at a maximal coverage and close seroepidemiologic surveillance are necessary in order to draw definite conclusions, because of the potentially strong impact of very dynamic ecological factors present in our geopolitical area upon the agent-host interrelationship.
在一个采用2+1剂量方案的白喉、破伤风、百日咳和脊髓灰质炎联合疫苗进行免疫接种的地区，对脊髓灰质炎和百日咳发病率进行了为期四年的监测，并进行了为期五年的血清学随访，结果表明：通过中和抗体的存在来衡量的针对脊髓灰质炎的个体保护在首次加强免疫五年后仍维持在非常充足的水平；在儿童百日咳抗体比例持续处于较高水平三年后，观察到显著下降，在加强免疫五年后，约28%的个体凝集素水平低于1:20；在该计划实施后的四年内，社区对麻痹性脊髓灰质炎和百日咳的保护效果令人满意。由于我们地缘政治区域存在的非常动态的生态因素对病原体-宿主相互关系可能产生强烈影响，因此有必要以最大覆盖率继续采用2+1剂量方案进行免疫接种并密切进行血清流行病学监测，以便得出明确结论。
