百日咳成分对儿童IPV DTP-脊髓灰质炎疫苗的佐剂作用缺乏。
Lack of adjuvant effect of the pertussis component on IPV DTP-polio vaccine in children.
作者信息
Cadoz M, Montagnon B, Yvonnet B, Xueref C, Vincent-Falquet J C, Bandet R, Gibelin N
出版信息
Dev Biol Stand. 1986;65:153-8.
On day 0, four groups of children (3 to 6 months old) randomly received IPV alone or IPV + pertussis, or IPV + DP, or IPV + DTP. At days 28 and 56, all the children received the same IPV + DTP vaccine. Polio neutralizing and diphtheria antibodies were determined at days 0, 28 and 56. No adjuvant and even some inhibitory effect of pertussis was observed at days 28 and 56 on mean polio antibody titers. These results are compared to those observed with diphtheria.
在第0天，四组3至6个月大的儿童随机单独接种脊髓灰质炎灭活疫苗（IPV），或接种IPV + 百日咳疫苗，或IPV + 白喉疫苗，或IPV + 白百破疫苗。在第28天和第56天，所有儿童均接种相同的IPV + 白百破疫苗。在第0天、第28天和第56天测定脊髓灰质炎中和抗体及白喉抗体。在第28天和第56天，未观察到百日咳疫苗对脊髓灰质炎平均抗体滴度有佐剂作用，甚至有一些抑制作用。将这些结果与白喉疫苗的观察结果进行比较。
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