Sarva R P, Shreiner D P, Van Thiel D, Yingvorapant N
J Nucl Med. 1985 Feb;26(2):140-4.
Cholescintigraphy with [99mTc] disofenin was used to determine the optimal dose and method of administration of the octapeptide of cholecystokinin, and to determine the kinetics of gallbladder filling and emptying in 22 patients without disease of the liver or gallbladder. The peak filling rate of the gallbladder occurred at 30 min after injection; filling was complete at 1 hr. A 45-min constant intravenous infusion of the octapeptide 20 ng/kg X hr resulted in progressive emptying of the normal gallbladder; the mean ejection fraction at 45 min was 77.2 +/- 4.9%. A 1-min injection of 20 ng/kg resulted in a rapid, short-lived emptying; the mean ejection fraction was 52.2 +/- 9.3%. Doubling or halving the infusion dose produced no greater response or a smaller response. We conclude that a constant 45-min infusion technique is superior to short injection times, because of more complete emptying, no side effects, and more consistent response.
采用[99mTc] 二异丙基乙氧羰甲基亚氨基二乙酸行肝胆闪烁显像，以确定胆囊收缩素八肽的最佳剂量和给药方法，并测定22例无肝脏或胆囊疾病患者胆囊充盈和排空的动力学。胆囊的最大充盈率出现在注射后30分钟；1小时时充盈完成。以20 ng/kg·小时的剂量持续静脉输注八肽45分钟可使正常胆囊逐渐排空；45分钟时的平均排空分数为77.2±4.9%。以20 ng/kg的剂量注射1分钟可导致快速、短暂的排空；平均排空分数为52.2±9.3%。输注剂量加倍或减半均未产生更大反应或更小反应。我们得出结论，持续45分钟的输注技术优于短时间注射，因为排空更完全、无副作用且反应更一致。
