Reduction of food intake by fencamfamine in rats.

Fencamfamine (1.0-10.0 mg/kg, i.p. single dose) reduced the food intake in a dose-effect relationship. The dose needed for the 50% inhibition of food intake (ID50) was 7.3 mg/kg. Fencamfamine-induced anorexia in rats (5.0 and 10.0 mg/kg) was followed by hyperactivity, stereotypy or both. Pretreatment with haloperidol antagonized the anoretic effect induced by fencamfamine. These findings suggest that the activation of central dopaminergic systems involved in feeding regulation may be responsible for the anoretic effect of fencamfamine and that this effect is associated with other central stimulant effects.