Ohfuji Satoko, Deguchi Masaaki, Tachibana Daisuke, Koyama Masayasu, Takagi Tetsu, Yoshioka Takayuki, Urae Akinori, Fukushima Wakaba, Hirota Yoshio
Department of Public Health, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka-city, Osaka 545-8585, Japan.
Department of Obstetrics and Gynecology, Kishiwada City Hospital, 1001, Gakuhara-cho, Kishiwada-city, Osaka 596-8501, Japan.
Vaccine. 2017 Aug 24;35(36):4811-4816. doi: 10.1016/j.vaccine.2017.07.006.
To evaluate influenza disease burden among pregnant women, an epidemiological study using the self-control method was conducted. Study subjects were 12,838 pregnant women who visited collaborating maternity hospitals and clinics in Osaka Prefecture, Japan, before the 2013/14 influenza season. As a study outcome, hospitalization due to respiratory illnesses between the 2010/11 and 2013/14 seasons was collected from each study subject through a baseline survey at the time of recruitment and a second survey after the 2013/14 season. The hospitalization rates during pregnancy and non-pregnancy periods was calculated separately. To compare the hospitalization rate during pregnancy with that during non-pregnancy within the same single study subject, Mantel-Haenzel rate ratios (RR) were calculated. During the four seasons examined in this study, nine and 17 subjects were hospitalized due to respiratory illnesses during pregnancy and non-pregnancy periods, respectively. The hospitalization rate was 2.54 per 10,000 woman-months during pregnancy and 1.08 per 10,000 woman-months during non-pregnancy. The RR for the hospitalization rate during pregnancy compared with that during non-pregnancy was 4.30 (95% confidence interval, 1.96-9.41). Our results suggest that during the influenza season, pregnant women have a higher risk than non-pregnant women for hospitalization due to respiratory illnesses. The self-control method appears to be an appropriate epidemiological method for evaluating the disease burden of influenza among pregnant women.
为评估孕妇流感疾病负担，开展了一项采用自身对照法的流行病学研究。研究对象为2013/14流感季节前到访日本大阪府合作妇产医院及诊所的12838名孕妇。作为研究结果，通过招募时的基线调查以及2013/14季节后的第二次调查，收集了每位研究对象在2010/11至2013/14季节期间因呼吸道疾病住院的情况。分别计算了孕期和非孕期的住院率。为比较同一研究对象孕期和非孕期的住院率，计算了Mantel-Haenzel率比（RR）。在本研究调查的四个季节中，孕期和非孕期分别有9名和17名研究对象因呼吸道疾病住院。孕期住院率为每10000妇女月2.54例，非孕期为每10000妇女月1.08例。孕期住院率与非孕期住院率的RR为4.30（95%置信区间，1.96 - 9.41）。我们的结果表明，在流感季节，孕妇因呼吸道疾病住院的风险高于非孕妇。自身对照法似乎是评估孕妇流感疾病负担的一种合适的流行病学方法。
