Division of Nephrology, University of Alberta, Edmonton, Alberta, Canada.
Division of Nephrology, Department of Medicine, McMaster University, St. Joseph's Hospital, Hamilton, Ontario, Canada.
Clin J Am Soc Nephrol. 2017 Sep 7;12(9):1518-1527. doi: 10.2215/CJN.01470217. Epub 2017 Aug 17.
The literature on strategies to increase the number of potential living kidney donors is extensive and has yet to be characterized. Scoping reviews are a novel methodology for systematically assessing a wide breadth of a given body of literature and may be done before conducting a more targeted systematic review.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We performed a scoping review and summarized the evidence for existing strategies to increase living kidney donation.
Our review identified seven studies that tested interventions using rigorous methods (, randomized, controlled trials) and outcome measures, all of which focused on using education targeted at potential recipients to increase living donation. Of these, two studies that targeted the potential recipients' close social network reported statistically significant results. Other interventions were identified, but their effect was assessed through quasiexperimental or observational study designs.
We identified an important gap in the literature for evidence-based strategies to increase living kidney donation. From the limited data available, strategies directed at potential recipients and their social networks are the most promising. These results can inform transplant programs that are considering strategies to increase living kidney donation and highlight the need for conduct of high-quality study to increase living donation.
关于增加潜在活体肾脏供体数量的策略的文献很多,但尚未对其进行描述。范围综述是一种新颖的方法,可用于系统评估给定文献的广泛范围,并且可以在进行更有针对性的系统审查之前进行。
设计、设置、参与者和测量:我们进行了范围综述,总结了增加活体肾脏捐赠的现有策略的证据。
我们的综述确定了七项使用严格方法(随机、对照试验)和结果测量来测试干预措施的研究,所有这些研究都集中在使用针对潜在受赠者的教育来增加活体捐赠。其中,两项针对潜在受赠者的密切社交网络的研究报告了具有统计学意义的结果。还确定了其他干预措施,但通过准实验或观察性研究设计评估了其效果。
我们发现,增加活体肾脏捐赠的基于证据的策略存在重要的文献空白。从现有有限的数据来看,针对潜在受赠者及其社交网络的策略最有希望。这些结果可以为正在考虑增加活体肾脏捐赠策略的移植计划提供信息,并强调需要进行高质量的研究来增加活体捐赠。