寨卡病毒感染的即时分子检测
Point-of-Care Molecular Test for Zika Infection.
作者信息
Mauk Michael G, Song Jinzhao, Bau Haim H, Liu Changchun
机构信息
Department of Mechanical Engineering and Applied Mechanics, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia PA.
出版信息
Clin Lab Int. 2017 Jun;41:25-27.
Abstract
The recent outbreak of Zika virus (ZIKV) infection has led to a serious threat to public health. Rapid and sensitive diagnostics for ZIKV infection are crucial because Zika infection is usually mild and often asymptomatic, but may have serious consequences to infants born to infected mothers. We report on a simple, sensitive, inexpensive, point-of-care (POC) diagnostic technology for rapid detection of ZIKV in saliva. We use a chemically heated cup for isothermal amplification without a need for electrical power. The detection results can be directly read out by eye.
摘要
最近寨卡病毒（ZIKV）感染的爆发对公众健康造成了严重威胁。针对ZIKV感染的快速且灵敏的诊断至关重要，因为寨卡感染通常症状轻微且常常无症状，但可能会对受感染母亲所生的婴儿造成严重后果。我们报告了一种用于在唾液中快速检测ZIKV的简单、灵敏、廉价的即时检测（POC）诊断技术。我们使用一个化学加热杯进行等温扩增，无需电力。检测结果可以直接肉眼读出。
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