Soares-da-Silva P
J Pharm Pharmacol. 1987 Feb;39(2):127-9. doi: 10.1111/j.2042-7158.1987.tb06958.x.
After sulpiride (75 mg kg-1) administration, a significant increase in dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) occurred in the rat striatum. No attenuation in the sulpiride-induced dopamine and DOPAC increase was seen in the striatum from rats previously treated with benztropine (25 mg kg-1). On the other hand, in the benztropine + sulpiride-treated group, HVA levels were significantly lower compared with those of rats to which only sulpiride had been given. The results presented suggest that under appropriate conditions, as when sulpiride is used, dopamine can be deaminated before its release has occurred.
给予舒必利（75毫克/千克）后，大鼠纹状体中的多巴胺、3,4-二羟基苯乙酸（DOPAC）和高香草酸（HVA）显著增加。在先前用苯海索（25毫克/千克）处理过的大鼠的纹状体中，未观察到舒必利诱导的多巴胺和DOPAC增加有所减弱。另一方面，在苯海索+舒必利处理组中，HVA水平与仅给予舒必利的大鼠相比显著降低。所呈现的结果表明，在适当条件下，如使用舒必利时，多巴胺可在释放前被脱氨基。
