Goel R K, Pathak N K, Biswas M, Pandey V B, Sanyal A K
J Pharm Pharmacol. 1987 Feb;39(2):138-40. doi: 10.1111/j.2042-7158.1987.tb06962.x.
Lapachol, a naphthaquinone isolated from the roots of Tectona grandis given at a dose of 5 mg kg-1 p.o. twice daily for 3 days was found to have an anti-ulcerogenic effect on subsequently induced experimental gastric and duodenal ulcers in rats and guinea-pigs. Its action appears to be associated with an effect on the protein content of gastric juice, and it reversed aspirin-induced changes in peptic activity, protein and sialic acid.
