Ge Qiu, Peng Wei, Zhang Jian, Weng Xuchu, Zhang Yong, Liu Thomas, Zang Yu-Feng, Wang Ze
Center for Cognition and Brain Disorders, Department of Psychology, Hangzhou Normal University, Hangzhou, China.
Department of Physics, Hangzhou Normal University, Hangzhou, China.
PLoS One. 2017 Aug 18;12(8):e0182182. doi: 10.1371/journal.pone.0182182. eCollection 2017.
Structural MRI (sMRI)-identified tissue "growth" after neuropsychological training has been reported in many studies but the origins of those apparent tissue changes (ATC) still remain elusive. One possible contributor to ATC is brain perfusion since T1-weighted MRI, the tool used to identify ATC, is sensitive to perfusion-change induced tissue T1 alterations. To test the hypothetical perfusion contribution to ATC, sMRI data were acquired before and after short-term global and regional perfusion manipulations via intaking a 200 mg caffeine pill and performing a sensorimotor task. Caffeine intake caused a global CBF reduction and apparent tissue density reduction in temporal cortex, anterior cingulate cortex, and the limbic area; sensorimotor task induced CBF increase and apparent tissue increase in spatially overlapped brain regions. After compensating CBF alterations through a voxel-wise regression, the ATC patterns demonstrated in both experiments were substantially suppressed. These data clearly proved existence of the perfusion contribution to short-term ATC, and suggested a need for correcting perfusion changes in longitudinal T1-weighted structural MRI analysis if a short-term design is used.
许多研究报告了神经心理学训练后结构磁共振成像（sMRI）所识别的组织“生长”，但这些明显的组织变化（ATC）的起源仍不清楚。ATC的一个可能因素是脑灌注，因为用于识别ATC的工具T1加权磁共振成像对灌注变化引起的组织T1改变敏感。为了测试灌注对ATC的假设贡献，在通过摄入200毫克咖啡因药丸和执行感觉运动任务进行短期整体和局部灌注操作之前和之后采集了sMRI数据。摄入咖啡因导致颞叶皮质、前扣带回皮质和边缘区域的整体脑血流量（CBF）减少以及表观组织密度降低；感觉运动任务在空间重叠的脑区诱导CBF增加和表观组织增加。通过体素回归补偿CBF改变后，两个实验中显示的ATC模式均被显著抑制。这些数据清楚地证明了灌注对短期ATC的贡献的存在，并表明如果采用短期设计，在纵向T1加权结构MRI分析中需要校正灌注变化。
