Macromolecular Chemistry, Bavarian Polymer Institute, University of Bayreuth , Universitätsstrasse 30, 95440 Bayreuth, Germany.
Department of Microbiology and Molecular Genetics, The Kuvin Centre for the Study of Infectious and Tropical Diseases, The Hebrew University of Jerusalem , Jerusalem, Israel.
Biomacromolecules. 2017 Oct 9;18(10):3215-3221. doi: 10.1021/acs.biomac.7b00852. Epub 2017 Aug 31.
Achieving high drug loading capacity and controlling drug delivery are two main challenges related to drug carriers. In this study, polymeric macroporous sponges with very high pore volume and large porosity are introduced as a new-type of drug carrier. Due to the high pore volume (285 and 166 cm/g for the sponges with densities of 3.5 and 6.0 mg/cm, respectively), the sponges exhibit very high drug loading capacities with average values of 1870 ± 114 and 2697 ± 73 mg/g in the present study, which is much higher than the meso and microporous drug carriers (<1500 mg/g). In order to control the release profiles, an additional poly(p-xylylene) (PPX) coating was deposited by chemical vapor deposition on the drug loaded sponge. Consequently, Artemisone (ART) release in the aqueous medium could be retarded, depending on the density of the sponge and the thickness of the coating. In future, the new 3D polymeric sponges would be highly beneficial as drug carriers for the programmed release of drugs for treatment of chronic diseases.
实现高载药量和控制药物释放是与药物载体相关的两个主要挑战。在这项研究中，引入了具有非常高孔体积和大孔隙率的聚合大孔海绵作为新型药物载体。由于高孔体积（密度为 3.5 和 6.0 mg/cm 的海绵的孔体积分别为 285 和 166 cm/g），在本研究中，海绵表现出非常高的载药量，平均值分别为 1870 ± 114 和 2697 ± 73 mg/g，远高于中孔和微孔药物载体（<1500 mg/g）。为了控制释放曲线，通过化学气相沉积在负载药物的海绵上沉积了额外的聚对二甲苯（PPX）涂层。因此，在水性介质中，青蒿素（ART）的释放可以根据海绵的密度和涂层的厚度来延迟。在未来，新型 3D 聚合物海绵将非常有益于作为用于治疗慢性病的药物的程序释放的药物载体。
