Lu Liangyu, Ma Mengyu, Gao Chengtao, Li Hongwei, Li Long, Dong Fuping, Xiong Yuzhu
College of Materials and Metallurgy, Guizhou University, Guiyang 550025, China.
National Engineering Research Center for Compounding and Modification of Polymer Materials, Guiyang 550025, China.
Pharmaceutics. 2020 Jan 25;12(2):98. doi: 10.3390/pharmaceutics12020098.
Modern pharmaceutics requires novel drug loading platforms with high drug loading capacity, controlled release, high stability, and good biocompacity. Metal-organic frameworks (MOFs) show promising applications in biomedicine owing to their extraordinarily high surface area, tunable pore size, and adjustable internal surface properties. However, MOFs have low stability due to weak coordinate bonding and limited biocompatibility, limiting their bioapplication. In this study, we fabricated MOFs/polysilsesquioxane (PSQ) nanocomposites and utilized them as drug carriers. Amine-functionalized MOF (UiO-66-NH) nanoparticles were synthesized and encapsulated with epoxy-functionalized polysilsesquioxane layer on the surface via a facile process. MOFs possessed high surface area and regular micropores, and PSQs offered stability, inertness, and functionality. The obtained UiO-66-NH@EPSQ nanocomposites were utilized as carriers for ibuprofen, a drug with carboxylic groups on the surface, and demonstrated high drug loading capacity and well-controlled release property. The UiO-66-NH@EPSQ nanocomposite exhibited low cytotoxicity to HeLa cells within a wide concentration range of 10-100 µg/mL, as estimated by the MTT method. The UiO-66-NH@EPSQ drug release system could be a potential platform in the field of controlled drug delivery.
现代药剂学需要具有高载药量、控释、高稳定性和良好生物相容性的新型药物负载平台。金属有机框架材料（MOFs）因其极高的比表面积、可调节的孔径和可调控的内表面性质，在生物医药领域展现出了广阔的应用前景。然而，由于其配位键较弱，MOFs的稳定性较低，生物相容性也有限，这限制了它们在生物医学中的应用。在本研究中，我们制备了MOFs/聚倍半硅氧烷（PSQ）纳米复合材料，并将其用作药物载体。通过简便的方法合成了氨基功能化的MOF（UiO-66-NH）纳米颗粒，并在其表面包覆了环氧功能化的聚倍半硅氧烷层。MOFs具有高比表面积和规则的微孔结构，而PSQs则提供了稳定性、惰性和功能性。所得的UiO-66-NH@EPSQ纳米复合材料被用作表面带有羧基的药物布洛芬的载体，并表现出高载药量和良好的控释性能。通过MTT法评估，UiO-66-NH@EPSQ纳米复合材料在10-100 µg/mL的宽浓度范围内对HeLa细胞表现出低细胞毒性。UiO-66-NH@EPSQ药物释放系统可能成为控释药物递送领域的一个潜在平台。
