Materials Research Institute, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Langmuir. 2010 Feb 2;26(3):1460-3. doi: 10.1021/la903571y.
The self-assembly of peptides, specifically dipeptides, offers numerous advantages for biological applications. We describe an easy, versatile method of fabricating different types of zwitterionic Phe-Phe dipeptide structures (i.e., tubes and vesicles) through solvent-mediated assembly. The stability of the dipeptide structures is increased by thin polymer coatings of poly(chloro-p-xylylene), a PPX film. We also investigated protein adsorption onto PPX-coated peptide tubes and vesicles by varying the thickness of the polymer film.
二肽的自组装，特别是二肽，为生物应用提供了许多优势。我们描述了一种通过溶剂介导组装来制备不同类型两性离子苯丙氨酸-苯丙氨酸二肽结构（即管和囊泡）的简单、通用的方法。通过聚（氯对二甲苯）的薄聚合物涂层增加了二肽结构的稳定性，即 PPX 膜。我们还通过改变聚合物膜的厚度研究了蛋白质在 PPX 涂层的肽管和囊泡上的吸附。
