School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM, China; Engineering & Technology Research Center for Chinese Materia Medica, Quality of the Universities of Guangdong Province, China.
School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Carbohydr Polym. 2017 Oct 15;174:48-56. doi: 10.1016/j.carbpol.2017.06.051. Epub 2017 Jun 15.
Osteoporosis is characterized by a reduction in bone mass and bone mineral density, which weakens the bone. Due to the side effects associated with drugs that are currently used to treat this disease, an increasing number of studies have focused on the research of effective ingredients derived from natural products. In particular, polysaccharides extracted from Chinese herbal medicines have received increasing attention. In this study, we isolated a homogeneous polysaccharide (COP90-1) from the dried rhizomes of Curculigo orchioides, a famous traditional Chinese medicine that is widely used in China, and determined its structure using the combined methods of chemical and spectral analyses. In addition, its effects on the proliferation and differentiation of primary mouse osteoblasts were assessed. The results showed that COP90-1 can effectively promote the proliferation and differentiation of primary osteoblasts in vitro. Additional studies are warranted to study the effects of this compound in vivo.
骨质疏松症的特征是骨量和骨矿物质密度减少，从而使骨骼变脆弱。由于目前用于治疗这种疾病的药物存在副作用，因此越来越多的研究集中在研究源自天然产物的有效成分上。特别是，从中药中提取的多糖受到了越来越多的关注。在这项研究中，我们从中国传统药材菝葜的干燥根茎中分离出一种均一多糖（COP90-1），并使用化学和光谱分析相结合的方法确定了其结构。此外，还评估了其对原代小鼠成骨细胞增殖和分化的影响。结果表明，COP90-1 可有效促进体外原代成骨细胞的增殖和分化。需要进一步的研究来研究该化合物在体内的作用。
