42例中东呼吸综合征冠状病毒感染患者根据疾病严重程度的血清学反应。
Serologic responses of 42 MERS-coronavirus-infected patients according to the disease severity.
作者信息
Ko Jae-Hoon, Müller Marcel A, Seok Hyeri, Park Ga Eun, Lee Ji Yeon, Cho Sun Young, Ha Young Eun, Baek Jin Yang, Kim So Hyun, Kang Ji-Man, Kim Yae-Jean, Jo Ik Joon, Chung Chi Ryang, Hahn Myong-Joon, Drosten Christian, Kang Cheol-In, Chung Doo Ryeon, Song Jae-Hoon, Kang Eun-Suk, Peck Kyong Ran
机构信息
Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea.
Institute of Virology, Charité - Universitätsmedizin Berlin, Berlin, Germany; German Centre for Infection Research, Germany.
出版信息
Diagn Microbiol Infect Dis. 2017 Oct;89(2):106-111. doi: 10.1016/j.diagmicrobio.2017.07.006. Epub 2017 Jul 14.
We evaluated serologic response of 42 Middle East respiratory syndrome coronavirus (MERS-CoV)-infected patients according to 4 severity groups: asymptomatic infection (Group 0), symptomatic infection without pneumonia (Group 1), pneumonia without respiratory failure (Group 2), and pneumonia progressing to respiratory failure (Group 3). None of the Group 0 patients showed seroconversion, while the seroconversion rate gradually increased with increasing disease severity (0.0%, 60.0%, 93.8%, and 100% in Group 0, 1, 2, 3, respectively; P = 0.001). Group 3 patients showed delayed increment of antibody titers during the fourth week, while Group 2 patients showed robust increment of antibody titer during the third week. Among patients having pneumonia, 75% of deceased patients did not show seroconversion by the third week, while 100% of the survived patients were seroconverted (P = 0.003).
我们根据4种严重程度分组评估了42例中东呼吸综合征冠状病毒（MERS-CoV）感染患者的血清学反应：无症状感染（0组）、有症状但无肺炎感染（1组）、有肺炎但无呼吸衰竭（2组）以及肺炎进展为呼吸衰竭（3组）。0组患者均未出现血清转化，而血清转化率随疾病严重程度增加而逐渐升高（0组、1组、2组、3组分别为0.0%、60.0%、93.8%和100%；P = 0.001）。3组患者在第四周抗体滴度出现延迟升高，而2组患者在第三周抗体滴度出现显著升高。在患有肺炎的患者中，75%的死亡患者在第三周未出现血清转化，而100%的存活患者出现了血清转化（P = 0.003）。
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