Zhang Xiang-Dong, Cheng Wang-Qiang, Wang Yong-Gang, Zhang Zheng
Taikang People's Hospital of Henan Province, Zhoukou 461400, China.
Zhongguo Zhong Yao Za Zhi. 2017 Jun;42(11):2181-2186. doi: 10.19540/j.cnki.cjcmm.2017.0099.
To observe the clinical efficacy of modified Da Chaihu decoction in treating essential hypertension with anxiety, the randomized, controlled, clinical trial was performed in this study. One hundred and twenty-six hypertensive patients with anxiety meeting the inclusive criteria were randomized into the treatment group and the control group. All of the included patients in the above 2 groups were treated by amlodipine besylate tablets. Patients in the treatment group were given Chinese herbal medicine modified Da Chaihu decoction every day. And patients in the control group were given flupentixol and melitracen tablets. The treatment course was 4 weeks. Blood pressure, the score of traditional Chinese medicine syndrome, blood lipids, C reactive protein, the Hamilton anxiety scale score and adverse effects were observed. It has been identified that, both systolic and diastolic blood pressure were significantly reduced (P<0.05). However, no significant difference between the treatment group and the control group was identified. For traditional Chinese medicine syndrome, it was significantly improved in the treatment group (P<0.05). For blood lipids, TC, TG, HDL-C, and LDL-C were significantly improved in the treatment group (P<0.05). After treatment, only TC was significantly reduced in the treatment group when compared to the control group (P<0.05). For C reactive protein, it was significantly reduced in the treatment group after treatment (P<0.05). For anxiety, no significant difference between the treatment group and the control group on the Hamilton anxiety scale score was identified. For adverse effect, no severe adverse effect was identified in this study. The modified Da Chaihu decoction maybe effective in the treatment of essential hypertension with anxiety. In addition to a certain role in lowering blood pressure, the modified Da Chaihu decoction was also effective in improving traditional Chinese medicine syndrome and blood lipids, reducing the level of C reactive protein, relieving anxiety with little adverse effect.
为观察加味大柴胡汤治疗原发性高血压伴焦虑症的临床疗效，本研究进行了随机对照临床试验。将126例符合纳入标准的高血压伴焦虑症患者随机分为治疗组和对照组。上述两组所有纳入患者均服用苯磺酸氨氯地平片。治疗组患者每日服用加味大柴胡汤中药。对照组患者服用氟哌噻吨美利曲辛片。疗程为4周。观察血压、中医证候评分、血脂、C反应蛋白、汉密尔顿焦虑量表评分及不良反应。结果表明，收缩压和舒张压均显著降低（P<0.05）。然而，治疗组与对照组之间未发现显著差异。对于中医证候，治疗组有显著改善（P<0.05）。对于血脂，治疗组的总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）均有显著改善（P<0.05）。治疗后，与对照组相比，治疗组仅总胆固醇显著降低（P<0.05）。对于C反应蛋白，治疗组治疗后显著降低（P<0.05）。对于焦虑症，治疗组与对照组在汉密尔顿焦虑量表评分上未发现显著差异。对于不良反应，本研究未发现严重不良反应。加味大柴胡汤可能对原发性高血压伴焦虑症有效。加味大柴胡汤除在降低血压方面有一定作用外，还能有效改善中医证候和血脂，降低C反应蛋白水平，缓解焦虑，不良反应少。
