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[中药丸剂剂型理论及应用现状分析]

[Analysis on dosage form theory and current application situation of traditional Chinese medicine pill].

作者信息

Zhang Zhen, Gao Tian-Hui, Fu Chao-Mei, Zhang Jin-Ming, Shi Jin-Feng, He Yao, Yin Heng, Jiang Mao-Yuan, Li Jie, Gao Fei

机构信息

The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research of Traditional Chinese Medicine, Macao University, Macao 999078, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2017 Jun;42(12):2408-2412. doi: 10.19540/j.cnki.cjcmm.20170416.001.

DOI:10.19540/j.cnki.cjcmm.20170416.001
PMID:28822200
Abstract

Traditional Chinese medicine(TCM) pill, the most representative and successive dosage form, is called as one of the four classical TCM dosage forms. "Pills could keep the lasting and lenitive therapeutic efficacy for a long period" is the most classical dosage form theory, showing a guidance significance in making recipe, preparations and clinic application. In this article, we would elucidate the inheritance and development significance of TCM pills in three key points, including dosage form theory, pharmaceutical preparation technology and clinic usage based on the pharmaceutics connotation of this theory. From this, it can provide the basis for researches on pills mechanism, material basis and mode of action in clinical application.

摘要

中药丸剂作为最具代表性且传承至今的剂型,被誉为中药四大经典剂型之一。“丸者,缓也,舒缓而治之”是最为经典的剂型理论,在方剂配伍、制剂及临床应用方面都具有指导意义。本文将基于该理论的药剂学内涵,从剂型理论、制剂工艺及临床应用三个关键点阐述中药丸剂的传承与发展意义。由此,可为临床应用中丸剂作用机制、物质基础及作用方式的研究提供依据。

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引用本文的文献

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Exploring the Scientific Rationality of the Phenomenon of "Different Dosage Forms of the Same Prescription" of Chinese Proprietary Medicine Based on Biopharmaceutical Properties of Powder and Pill of Chuanxiong Chatiao Prescription.基于川芎茶调方散剂与丸剂生物药剂学性质探讨中成药“同方不同剂型”现象的科学合理性
Front Pharmacol. 2022 Jun 9;13:893552. doi: 10.3389/fphar.2022.893552. eCollection 2022.
2
An Integrated Gut Microbiota and Network Pharmacology Study on Fuzi-Lizhong Pill for Treating Diarrhea-Predominant Irritable Bowel Syndrome.基于肠道菌群与网络药理学的附子理中丸治疗腹泻型肠易激综合征的研究
Front Pharmacol. 2021 Nov 30;12:746923. doi: 10.3389/fphar.2021.746923. eCollection 2021.
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Traditional Chinese Medicine "Pill", an Ancient Dosage Form with Surprising Modern Pharmaceutical Characteristics.
中药“丸剂”,一种具有惊人现代药学特性的古老剂型。
Pharm Res. 2021 Feb;38(2):199-211. doi: 10.1007/s11095-021-03007-x. Epub 2021 Feb 18.
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The clinical benefits of Chinese patent medicines against COVID-19 based on current evidence.基于现有证据的抗 COVID-19 中药的临床获益。
Pharmacol Res. 2020 Jul;157:104882. doi: 10.1016/j.phrs.2020.104882. Epub 2020 May 5.
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Rapid discovery of chemical constituents and absorbed components in rat serum after oral administration of Fuzi-Lizhong pill based on high-throughput HPLC-Q-TOF/MS analysis.基于高通量HPLC-Q-TOF/MS分析快速发现附子理中丸口服给药后大鼠血清中的化学成分及吸收成分
Chin Med. 2019 Mar 1;14:6. doi: 10.1186/s13020-019-0227-z. eCollection 2019.