Quinton D N, O'Byrne G, Aitkenhead A R
Lancet. 1987 Apr 11;1(8537):828-9. doi: 10.1016/s0140-6736(87)91608-4.
Twelve patients presenting to an accident and emergency department in asystolic cardiac arrest were randomly allocated to treatment with endotracheal adrenaline (five patients) or peripheral intravenous adrenaline (seven patients). Femoral-artery blood samples were taken for assay of adrenaline and noradrenaline. After intravenous adrenaline there was a good clinical and biochemical response, but after endotracheal adrenaline there was no change in serum adrenaline and no measurable clinical response. The endotracheal route of adrenaline administration is not reliable in out-of-hospital cardiac arrest.
12名因心脏停搏而被送至急诊科的患者被随机分配接受气管内注射肾上腺素治疗（5例）或外周静脉注射肾上腺素治疗（7例）。采集股动脉血样以检测肾上腺素和去甲肾上腺素。静脉注射肾上腺素后出现了良好的临床和生化反应，但气管内注射肾上腺素后血清肾上腺素无变化，也未观察到可测量的临床反应。在院外心脏骤停时，气管内注射肾上腺素的给药途径不可靠。
