Li Z W, Zhou S H
First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Aug 7;52(8):637-639. doi: 10.3760/cma.j.issn.1673-0860.2017.08.021.
The laryngopharyngeal reflux disease (LPRD) is a general term for a series of symptoms and signs caused by reflux of the stomach contents to the upper part of the esophageal sphincter. In recent years, the laryngopharyngeal reflux (LPR) is getting more and more attention as laryngeal precancerous lesions and risk factors of laryngeal cancer. Laryngeal precancerous lesions plays a important role in the development of laryngeal cancer process. This article will review the role and mechanisms of LPR in the laryngeal precancerous lesions, and the status of anti-reflux in the treatment of laryngeal precancerous lesions.
喉咽反流病(LPRD)是指胃内容物反流至食管上括约肌以上部位所引起的一系列症状和体征的总称。近年来,喉咽反流(LPR)作为喉癌前病变及喉癌的危险因素越来越受到关注。喉癌前病变在喉癌发生发展过程中起重要作用。本文将综述LPR在喉癌前病变中的作用及机制,以及抗反流治疗在喉癌前病变治疗中的现状。