Gao Yuxia, Zhao Huayao, Jin Yin, Xu Xiaoyu, Han Guan-Zhu
Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210046, China.
Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210046, China.
Virus Res. 2017 Aug 15;240:161-165. doi: 10.1016/j.virusres.2017.08.005. Epub 2017 Aug 16.
Gene duplication is the main source of genomic novelties and complexities for both eukaryotes and prokaryotes. In contrast, gene duplication appears to be infrequent in the RNA viruses. However, the extent and evolution of gene duplication in DNA viruses remains obscure. Here we perform a genome-wide analysis of gene duplication in the genomes of 250 DNA viruses that represent all known DNA viral genera. While no gene duplication event is identified in single stranded DNA (ssDNA) or reverse transcribing DNA viruses, gene duplication is frequent among double stranded DNA (dsDNA) viruses. For dsDNA viruses, the number of duplicate genes is significantly correlated with the genome complexity. We find that most of duplicate genes experienced purifying selection on average. Our results indicate that gene duplication play an important role in shaping the evolution of dsDNA viruses.
基因复制是真核生物和原核生物基因组新奇性和复杂性的主要来源。相比之下，基因复制在RNA病毒中似乎很少见。然而，DNA病毒中基因复制的程度和进化仍不清楚。在这里，我们对代表所有已知DNA病毒属的250种DNA病毒的基因组进行了全基因组范围的基因复制分析。虽然在单链DNA（ssDNA）或逆转录DNA病毒中未发现基因复制事件，但基因复制在双链DNA（dsDNA）病毒中很常见。对于dsDNA病毒，重复基因的数量与基因组复杂性显著相关。我们发现，大多数重复基因平均经历了纯化选择。我们的结果表明，基因复制在塑造dsDNA病毒的进化中起着重要作用。
