School of Mechanical, Materials, Mechatronic and Biomedical Engineering, University of Wollongong, Wollongong, NSW 2522, Australia.
School of Mechanical, Materials, Mechatronic and Biomedical Engineering, University of Wollongong, Wollongong, NSW 2522, Australia; ARC Center of Excellence for Electromaterials Science, University of Wollongong, 2522 NSW, Australia.
J Colloid Interface Sci. 2017 Dec 15;508:87-94. doi: 10.1016/j.jcis.2017.08.033. Epub 2017 Aug 12.
Tissue and biomedical engineering fields are in constant mutation and in searching for innovative processing techniques capable to tailor the material properties. In this work, poly(l-lactic acid) (PLLA) and elastomeric poly(glycerol sebacate) (PGS) were dissolved in the same solvents and electrospun together, in a single needle system. A core-shell structure where the hydrophilic PGS was placed onto the surface of the hydrophobic PLLA fibre was obtained for elastomeric concentrations up to 25wt%. It was found that the PLLA:PGS blends are immiscible and the blends present the melting temperatures of the individual polymers. Moreover, their surface properties were deeply influenced by the presence of the PGS, and a superhydrophilic membrane was obtained, after PGS curing at 120°C for 48h. When the concentration of PGS is up to 25wt%, the blend's Young modulus decreases from ∼35.9±7.1 to 7.5±1.4MPa and a twofold improvement in the sample stretchability was observed, compared with the pristine PLLA electrospun samples. Finally, in vitro hypothalamus A59 nerve cell culture shows that the core-shell electrospun samples enhanced cell adhesion and proliferation, suggesting that these developed materials have great potentials for nerve regeneration and biomedical engineering applications.
组织和生物医学工程领域正在不断变化，人们一直在寻找创新的处理技术，以调整材料的特性。在这项工作中，聚（L-丙交酯）（PLLA）和弹性聚（甘油 - 癸二酸酯）（PGS）在相同的溶剂中溶解，并在单针系统中一起进行静电纺丝。对于弹性体浓度高达 25wt％的情况，获得了亲水 PGS 置于疏水性 PLLA 纤维表面的核壳结构。发现 PLLA:PGS 共混物是不混溶的，并且共混物具有各个聚合物的熔融温度。此外，它们的表面性能受到 PGS 的存在的深刻影响，并且在 PGS 在 120°C 下固化 48 小时后，得到超亲水膜。当 PGS 的浓度高达 25wt％时，与原始 PLLA 静电纺丝样品相比，共混物的杨氏模量从约 35.9±7.1 降低至 7.5±1.4MPa，并且观察到样品拉伸性能提高了两倍。最后，体外下丘脑 A59 神经细胞培养表明，核壳静电纺丝样品增强了细胞黏附和增殖，表明这些开发的材料在神经再生和生物医学工程应用方面具有巨大的潜力。
