Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden; Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Prev Med. 2017 Dec;105:37-46. doi: 10.1016/j.ypmed.2017.08.008. Epub 2017 Aug 16.
Previous research has shown positive effects of exercise on depression but studies have mainly focused on the short-term effects; few have examined the long-term effect, especially with regard to differences in intensity. The aim of this study was to examine the long-term effects of prescribed exercise on depression, performed at three intensity levels. People aged 18-67years with mild to moderate depression (Patient Health Questionnaire-9 score of ≥10) participated in a single-blind, parallel randomized control trial lasting 12weeks (Sweden 2011-2013). Four arms were included: Treatment as usual (TAU, n=310), light (n=106), moderate (n=105) and vigorous exercise (n=99). Severity of depression was measured at baseline, post-treatment and 12-month follow-up using the Montgomery-Åsberg Depression Rating Scale (MADRS). Coefficients (β) and odds ratios were estimated using linear mixed models with time×group interactions. The results showed that at the 12month follow-up the light exercise group had significantly lower depression severity scores than the TAU (-1.9, 95% CI: -3.7, -0.04) and the moderate exercise group (-2.94 95% CI: -5.2, -0.7). The vigorous exercise group had significantly lower scores than the moderate exercise group only (-2.7, 95% CI: -4.9, -0.4). In conclusion, compared to usual care for depression, only light exercise resulted in significantly lower depression severity at 12-month follow-up. Both light and vigorous exercise was more effective than moderate exercise.
The study was registered with the German Clinical Trial Register (DRKS study ID: DRKS00008745).
先前的研究表明，运动对抑郁症有积极影响，但这些研究主要集中在短期效果上；很少有研究考察长期效果，尤其是在强度方面的差异。本研究旨在考察以三种强度水平进行的规定运动对抑郁症的长期影响。年龄在 18-67 岁之间、患有轻度至中度抑郁症（患者健康问卷-9 得分≥10）的参与者参加了一项为期 12 周的单盲、平行随机对照试验（瑞典，2011-2013 年）。共包括四个组：常规治疗（TAU，n=310）、轻度（n=106）、中度（n=105）和剧烈运动（n=99）。使用蒙哥马利-阿斯伯格抑郁评定量表（MADRS）在基线、治疗后和 12 个月随访时测量抑郁严重程度。使用线性混合模型和时间×组交互作用估计系数（β）和优势比。结果表明，在 12 个月随访时，与 TAU 组（-1.9，95%CI：-3.7，-0.04）和中度运动组（-2.94，95%CI：-5.2，-0.7）相比，轻度运动组的抑郁严重程度评分显著降低。与中度运动组相比，剧烈运动组的评分也显著降低（-2.7，95%CI：-4.9，-0.4）。总之，与常规治疗抑郁症相比，只有轻度运动在 12 个月随访时显著降低了抑郁严重程度。轻度和剧烈运动都比中度运动更有效。
该研究在德国临床试验注册中心（DRKS 研究 ID：DRKS00008745）注册。
