Toyoshima Atsuhiko, Yasuhara Takao, Date Isao
Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558,
Acta Med Okayama. 2017 Aug;71(4):263-268. doi: 10.18926/AMO/55302.
To date, many animal studies have indicated the neuroprotective effects of mesenchymal stem cell (MSC) transplantation in ischemic stroke. Several clinical studies have also revealed the safety, feasibility, and neuroprotective effects in ischemic stroke patients. In this review, we present the main approaches of MSC transplantation in ischemic stroke, the mechanisms of MSC therapy, and the current clinical studies on MSC transplantation in ischemic stroke patients. We also explore the safety of MSC transplantation and conclude that MSC therapy will play an important role in the future treatment of ischemic stroke. The optimal timing, approach, and cell dose in the transplantation are important issues for successful clinical application.
迄今为止，许多动物研究已表明间充质干细胞（MSC）移植对缺血性中风具有神经保护作用。多项临床研究也揭示了其在缺血性中风患者中的安全性、可行性及神经保护作用。在本综述中，我们介绍了MSC移植治疗缺血性中风的主要途径、MSC治疗的机制以及目前针对缺血性中风患者进行MSC移植的临床研究。我们还探讨了MSC移植的安全性，并得出结论：MSC治疗将在未来缺血性中风的治疗中发挥重要作用。移植的最佳时机、途径和细胞剂量是临床成功应用的重要问题。
