Oh Yeonsu, Kwon Yong-Soo, Jung Bae Dong
College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University, Chuncheon, 24341, Republic of Korea.
College of Pharmacy, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Int J Med Sci. 2017 Jul 18;14(8):729-734. doi: 10.7150/ijms.19616. eCollection 2017.
Pelvic inflammatory disease (PID) is an inflammatory and/or infectious disorder of the upper female genital tract, including the uterus, fallopian tubes, and adjacent pelvic structures, that may spread upward to the peritoneum. Currently available treatment options have presented to produce adverse effects of various degrees, such as increased antimicrobial resistance and a limited effective duration of hormones. In the study, the Cortex (CP) and (HJ) among natural compounds that are believed to present biological activities with fewer side effects were tested in a PID animal model. The results suggested that the administration CP and HJ reduced clinical signs, inflammatory cytokine expression as well as secretion in uterine tissue, and neutrophil infiltration into the tissue.
盆腔炎（PID）是女性上生殖道的一种炎症性和/或感染性疾病，包括子宫、输卵管及邻近的盆腔结构，可向上蔓延至腹膜。目前可用的治疗方案已出现各种程度的不良反应，如抗菌药物耐药性增加和激素有效持续时间有限。在该研究中，在PID动物模型中测试了天然化合物中被认为具有较少副作用且具有生物活性的皮层（CP）和（HJ）。结果表明，给予CP和HJ可减轻临床症状、降低子宫组织中炎性细胞因子的表达及分泌，并减少中性粒细胞向组织内浸润。
