Hardy J, Cowburn R, Barton A, Reynolds G, Lofdahl E, O'Carroll A M, Wester P, Winblad B
Neurosci Lett. 1987 Jan 2;73(1):77-80. doi: 10.1016/0304-3940(87)90034-6.
Synaptosomal D-aspartate has been used as a marker for glutamate neurons in control and in postmortem Alzheimer's disease brains. This technique shows a marked (60%) decrease of the glutamate uptake site in cortical and hippocampal regions. There were no significant changes in subcortical regions. We interpret these results as indicating loss of, or damage to, cortical glutamatergic innervation. These losses probably represent the biochemical correlate of pyramidal neuron damage in Alzheimer's disease.
突触体D-天冬氨酸已被用作对照和死后阿尔茨海默病大脑中谷氨酸能神经元的标志物。该技术显示皮质和海马区域中谷氨酸摄取位点显著减少（60%）。皮质下区域没有明显变化。我们将这些结果解释为表明皮质谷氨酸能神经支配的丧失或损伤。这些损失可能代表了阿尔茨海默病中锥体神经元损伤的生化关联。
