Pahari Susanta, Kaur Gurpreet, Aqdas Mohammad, Negi Shikha, Chatterjee Deepyan, Bashir Hilal, Singh Sanpreet, Agrewala Javed N
Immunology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India.
Front Immunol. 2017 Aug 2;8:906. doi: 10.3389/fimmu.2017.00906. eCollection 2017.
The global control of tuberculosis (TB) presents a continuous health challenge to mankind. Despite having effective drugs, TB still has a devastating impact on human health. Contributing reasons include the emergence of drug-resistant strains of , the AIDS-pandemic, and the absence of effective vaccines against the disease. Indeed, alternative and effective methods of TB treatment and control are urgently needed. One such approach may be to more effectively engage the immune system; particularly the frontline pattern recognition receptor (PRR) systems of the host, which sense pathogen-associated molecular patterns (PAMPs) of . It is well known that 95% of individuals infected with in latent form remain healthy throughout their life. Therefore, we propose that clues can be found to control the remainder by successfully manipulating the innate immune mechanisms, particularly of nasal and mucosal cavities. This article highlights the importance of signaling through PRRs in restricting entry and subsequently preventing its infection. Furthermore, we discuss whether this unique therapy employing PRRs in combination with drugs can help in reducing the dose and duration of current TB regimen.
结核病（TB）的全球防控对人类健康构成了持续挑战。尽管有有效的药物，但结核病仍对人类健康产生毁灭性影响。促成因素包括耐药菌株的出现、艾滋病大流行以及缺乏针对该疾病的有效疫苗。事实上，迫切需要替代且有效的结核病治疗和控制方法。一种这样的方法可能是更有效地调动免疫系统；特别是宿主的一线模式识别受体（PRR）系统，该系统可感知结核分枝杆菌的病原体相关分子模式（PAMP）。众所周知，95% 潜伏感染结核分枝杆菌的个体一生都保持健康。因此，我们建议可以通过成功操纵先天免疫机制，特别是鼻腔和粘膜腔的先天免疫机制，找到控制其余感染者的线索。本文强调了通过PRR发出信号在限制结核分枝杆菌进入并随后预防其感染方面的重要性。此外，我们讨论了这种将PRR与药物联合使用的独特疗法是否有助于减少当前结核病治疗方案的剂量和疗程。
