Harris R A, Snell D, Loh H H
Pharmacol Biochem Behav. 1977 Oct;7(4):307-10. doi: 10.1016/0091-3057(77)90225-8.
The effects of R(-)-, S(+) and R, S-1-2-5-dimethoxy-4-methylphenyl)-2-Aminopropane (DOM) were studied using rats responding under a fixed interval two-min schedule of food presentation. All three drugs decreased average rates of responding in a dose-related manner, with R -DOM being five to six times more potent than S-DOM increased the low response rates occurring at the beginning of the fixed interval and decreased the higher response rates occurring at the end of the interval (rate-dependent effects). These results are discussed in terms of the stereoselective metabolism of DOM and of the structural similarities between R-DOM and the behaviorally active isomer of LSD.
使用在固定间隔两分钟食物呈现时间表下做出反应的大鼠，研究了R(-)-、S(+)和R,S-1-(2,5-二甲氧基-4-甲基苯基)-2-氨基丙烷（DOM）的作用。所有三种药物均以剂量相关的方式降低了平均反应率，其中R-DOM的效力比S-DOM高五到六倍，增加了固定间隔开始时出现的低反应率，并降低了间隔结束时出现的高反应率（速率依赖性效应）。根据DOM的立体选择性代谢以及R-DOM与LSD行为活性异构体之间的结构相似性对这些结果进行了讨论。
