Centre for Brain Research, The University of Auckland, Auckland, New Zealand.
Elife. 2017 Aug 22;6:e25062. doi: 10.7554/eLife.25062.
Exercise-induced cognitive improvements have traditionally been observed following aerobic exercise interventions; that is, sustained sessions of moderate intensity. Here, we tested the effect of a 6 week high-intensity training (HIT) regimen on measures of cognitive control and working memory in a multicenter, randomized (1:1 allocation), placebo-controlled trial.
318 children aged 7-13 years were randomly assigned to a HIT or an active control group matched for enjoyment and motivation. In the primary analysis, we compared improvements on six cognitive tasks representing two cognitive constructs ( = 305). Secondary outcomes included genetic data and physiological measurements.
The 6-week HIT regimen resulted in improvements on measures of cognitive control [BF = 3.38, = 0.31 (0.09, 0.54)] and working memory [BF = 5233.68, = 0.54 (0.31, 0.77)], moderated by genotype, with met carriers showing larger gains post-exercise than val homozygotes.
This study suggests a promising alternative to enhance cognition, via short and potent exercise regimens.
Funded by Centre for Brain Research.
NCT03255499.
传统上，有氧运动干预后会观察到与运动相关的认知改善；也就是说，适度强度的持续运动。在这里，我们在一项多中心、随机（1:1 分配）、安慰剂对照试验中测试了 6 周高强度训练（HIT）方案对认知控制和工作记忆测量的影响。
318 名 7-13 岁的儿童被随机分配到 HIT 或与享受和动机相匹配的积极对照组。在主要分析中，我们比较了六个代表两种认知结构的认知任务的改善情况（n=305）。次要结果包括遗传数据和生理测量。
6 周的 HIT 方案导致认知控制测量值提高[BF=3.38，=0.31（0.09，0.54）]和工作记忆提高[BF=5233.68，=0.54（0.31，0.77）]，受基因型调节，携带 met 等位基因的个体比 val 纯合子在运动后有更大的收益。
这项研究表明，通过短期而有效的运动方案，是一种有前途的增强认知的替代方法。
由脑研究中心资助。
NCT03255499。
