蛋白激酶 C 同工型在正常胰腺和胰腺疾病中的作用。
Protein kinase C isoforms in the normal pancreas and in pancreatic disease.
机构信息
Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.
Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.
出版信息
Cell Signal. 2017 Dec;40:1-9. doi: 10.1016/j.cellsig.2017.08.005. Epub 2017 Aug 18.
Abstract
Protein Kinase C isoforms have been implicated in regulating multiple processes within the healthy pancreas. Moreover, their dysregulation contributes to all aspects of pancreatic disease. In this review, with a focus on acinar, ductal, and islet cells, we highlight the roles and contributions of the different PKC isoforms to normal pancreas function. We also discuss the contribution of PKC enzymes to pancreatic diseases, including insulin resistance and diabetes mellitus, as well as pancreatitis and the development and progression of pancreatic cancer.
摘要
蛋白激酶 C 同工型已被牵涉到调节健康胰腺中的多个过程。此外，它们的失调导致了胰腺疾病的各个方面。在这篇综述中，我们重点关注腺泡、导管和胰岛细胞，强调了不同蛋白激酶 C 同工型对正常胰腺功能的作用和贡献。我们还讨论了蛋白激酶 C 酶对包括胰岛素抵抗和糖尿病、胰腺炎以及胰腺癌的发展和进展在内的胰腺疾病的贡献。
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