González-Bello Concepción
Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela, Jenaro de la Fuente s/n, 15782 Santiago de Compostela, Spain.
Bioorg Med Chem Lett. 2017 Sep 15;27(18):4221-4228. doi: 10.1016/j.bmcl.2017.08.027. Epub 2017 Aug 14.
Resistance to available antibiotics in pathogenic bacteria is currently a global challenge since the number of strains that are resistant to multiple types of antibiotics has increased dramatically each year and has spread worldwide. To unlock this problem, the use of an 'antibiotic adjuvant' in combination with an antibiotic is now being exploited. This approach enables us to prolong the lifespan of these life-saving drugs. This digests review provides an overview of the main types of antibiotic adjuvants, the basis of their operation and the remaining issues to be tackled in this field. Particular emphasis is placed on those compounds that are already in clinical development, namely β-lactamase inhibitors.
致病性细菌对现有抗生素产生耐药性目前是一个全球性挑战，因为对多种抗生素耐药的菌株数量每年都在急剧增加，且已在全球范围内传播。为了解决这个问题，目前正在探索将“抗生素佐剂”与抗生素联合使用。这种方法使我们能够延长这些救命药物的使用寿命。本综述概述了抗生素佐剂的主要类型、其作用基础以及该领域有待解决的剩余问题。特别强调了那些已进入临床开发阶段的化合物，即β-内酰胺酶抑制剂。
