Probes for Targets Group (P4T group), Department of food and Drug, University of Parma, 43124 Parma, Italy.
Int J Mol Sci. 2019 Nov 21;20(23):5844. doi: 10.3390/ijms20235844.
Antibiotics have always been considered as one of the most relevant discoveries of the twentieth century. Unfortunately, the dawn of the antibiotic era has sadly corresponded to the rise of the phenomenon of antimicrobial resistance (AMR), which is a natural process whereby microbes evolve in such a way to withstand the action of drugs. In this context, the identification of new potential antimicrobial targets and/or the identification of new chemical entities as antimicrobial drugs are in great demand. To date, among the many possible approaches used to deal with antibiotic resistance is the use of antibiotic adjuvants that hit bacterial non-essential targets. In this review, the author focuses on the discovery of antibiotic adjuvants and on new tools to study and reduce the prevalence of resistant bacterial infections.
抗生素一直被认为是 20 世纪最相关的发现之一。不幸的是，抗生素时代的曙光可悲地对应着抗菌药物耐药性（AMR）现象的兴起，这是一种微生物通过进化以抵抗药物作用的自然过程。在这种情况下，人们非常需要确定新的潜在抗菌靶标和/或确定新的化学实体作为抗菌药物。迄今为止，用于应对抗生素耐药性的许多可能方法中，有一种是使用针对细菌非必需靶标的抗生素佐剂。在这篇综述中，作者重点介绍了抗生素佐剂的发现以及研究和减少耐药细菌感染流行的新工具。
