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三维伪连续动脉自旋标记揭示（-）-芳樟醇对健康男性志愿者脑血流量的影响

(-)-Linalool influence on the cerebral blood flow in healthy male volunteers revealed by three-dimensional pseudo-continuous arterial spin labeling.

作者信息

Ota Miho, Sato Noriko, Sone Daichi, Ogura Jun, Kunugi Hiroshi

机构信息

Department of Mental Disorder Research, National Institute of Neuroscience, Kodaira, Tokyo 187-8551, Japan.

Department of Radiology, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8551, Japan.

出版信息

Indian J Psychiatry. 2017 Apr-Jun;59(2):225-227. doi: 10.4103/psychiatry.IndianJPsychiatry_323_16.

DOI:10.4103/psychiatry.IndianJPsychiatry_323_16
PMID:28827872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5547866/
Abstract

BACKGROUND

Although aromatherapy is widely used, the pharmacology of the essential oils remains undiscovered.

AIM

The present study assessed the effect of (-)-linalool, the main contained material of lavender, on the brain function.

MATERIALS AND METHODS

Healthy male volunteers calculated the regional cerebral blood flow (CBF) before and after inhalation of (-)-linalool, and CBF changes were evaluated.

RESULTS

There were significant CBF reductions in the right superior temporal gyrus to insula, anterior cingulate cortex after inhalation.

CONCLUSIONS

The previous study detected the regulatory influence of (-)-linalool on the glutamatergic transmission. The effect of (-)-linalool on the ACC and insula would cause the sedative and anxiolytic activity.

摘要

背景

尽管芳香疗法被广泛应用，但精油的药理学仍未被揭示。

目的

本研究评估薰衣草的主要成分（-）-芳樟醇对脑功能的影响。

材料与方法

健康男性志愿者在吸入（-）-芳樟醇前后计算局部脑血流量（CBF），并评估CBF的变化。

结果

吸入后右侧颞上回至脑岛、前扣带回皮质的CBF显著降低。

结论

先前的研究检测到（-）-芳樟醇对谷氨酸能传递的调节作用。（-）-芳樟醇对前扣带回皮质和脑岛的作用会导致镇静和抗焦虑活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23d9/5547866/1bba7959be4f/IJPsy-59-225-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23d9/5547866/1bba7959be4f/IJPsy-59-225-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23d9/5547866/1bba7959be4f/IJPsy-59-225-g001.jpg

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本文引用的文献

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Abnormalities of cerebral blood flow in multiple sclerosis: a pseudocontinuous arterial spin labeling MRI study.多发性硬化症中的脑血流异常：一项伪连续动脉自旋标记 MRI 研究。
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Olfactory system and emotion: common substrates.嗅觉系统与情绪：共同的基础。
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Aromatherapy in the management of psychiatric disorders: clinical and neuropharmacological perspectives.芳香疗法在精神疾病管理中的应用：临床与神经药理学视角
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Sedative effects of the jasmine tea odor and (R)-(-)-linalool, one of its major odor components, on autonomic nerve activity and mood states.茉莉花茶气味及其主要气味成分之一（R）-（-）-芳樟醇对自主神经活动和情绪状态的镇静作用。
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Aromas of rosemary and lavender essential oils differentially affect cognition and mood in healthy adults.迷迭香和薰衣草精油的香气对健康成年人的认知和情绪有不同影响。
Int J Neurosci. 2003 Jan;113(1):15-38. doi: 10.1080/00207450390161903.
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Phytother Res. 2001 Aug;15(5):422-5. doi: 10.1002/ptr.973.
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Olfaction.嗅觉。
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