Singal Rikki, Dhar Siddharth, Zaman Muzzafar, Singh Bir, Singh Varsha, Sethi Sheena
Department of Surgery, Maharishi Markandeshwer Institute of Medical Sciences and Research, Mullana, (Distt-Ambala), Haryana, India.
Department of Microbiology, Maharishi Markandeshwer Institute of Medical Sciences and Research, Mullana, Ambala, Haryana, India.
Maedica (Bucur). 2016 Dec;11(4):277-285.
To investigate the efficacy of super-oxidized solution (SOS) over normal saline in peritonitis cases. Our objectives are to present the potential clinical impact of intraperitoneal lavage with solutions for early recovery of the patient by reducing the infection rate.
A double-blind random clinical trial was performed in 240 cases diagnosed as peritonitis at MM Institute of Medical Sciences and Research, Mullana, Ambala, India, from December 2013 to November 2015. Subjects were categorized into 2 groups, i.e. 120 cases in the group I and 120 cases in the group II. Both the groups underwent peritoneal lavage; the group I underwent normal saline lavage and group II received SOS. The effectiveness of both the solutions was compared.
In both the groups majority of the patients (50.0%) were in the 21 - 40 years of age. The mean age in our study was 45.28 years, median was 45 and the standard deviation was 14.07. The bacterial load was higher in the group II as compared to the group I after the lavage with SOS solution. The superficial wound infection rate was higher in the group II (48 cases) compared to the group I (32). These data was significant with p value (0.040). Wound pain was found in 59 cases in group II as compared to 42 in group I. This difference was found to be statistically significant with p value 0.036. Post-operatively the morbidity and mortality was less in the group I as compared to group II.
SOS significantly reduced the wound pain and infection hence resulting in early recovery. SOS is a high level disinfectant, non-flammable and no special training is required to handle it.
研究超氧化溶液（SOS）在腹膜炎病例中相对于生理盐水的疗效。我们的目标是通过降低感染率来呈现腹腔灌洗溶液对患者早期康复的潜在临床影响。
2013年12月至2015年11月期间，在印度安巴拉穆拉纳MM医学科学与研究所对240例诊断为腹膜炎的患者进行了一项双盲随机临床试验。受试者分为两组，即第一组120例和第二组120例。两组均接受腹腔灌洗；第一组接受生理盐水灌洗，第二组接受SOS灌洗。比较两种溶液的有效性。
两组中大多数患者（50.0%）年龄在21 - 40岁之间。我们研究中的平均年龄为45.28岁，中位数为45岁，标准差为14.07。用SOS溶液灌洗后，第二组的细菌载量高于第一组。第二组（48例）的浅表伤口感染率高于第一组（32例）。这些数据具有显著性，p值为（0.040）。第二组有59例出现伤口疼痛，而第一组为42例。发现这种差异具有统计学显著性，p值为0.036。术后第一组的发病率和死亡率低于第二组。
SOS显著减轻了伤口疼痛和感染，从而实现了早期康复。SOS是一种高效消毒剂，不易燃，处理时无需特殊培训。
