Saglam Y, Kizildag H, Toprak G, Alp N B, Yalcinkaya E Y
Biruni University, Medical Faculty, Orthopedics and Traumatology Department, Istanbul, Turkey.
Bahgelievler State Hospital, Department of Pediatrics, Istanbul, Turkey.
J Child Orthop. 2017 Jun 1;11(3):180-184. doi: 10.1302/1863-2548.11.160008.
This study aimed to determine whether children with distal radius impaction fractures have increased prevalence of 25-hydroxyvitamin D (25(OH) D) insufficiency compared with healthy controls.
This is a prospective controlled study. The 30 children who were diagnosed with forearm fracture at the orthopaedic emergency clinic were included in the study and 30 healthy children from the routine paediatric outpatient unit were included as the control group. Peripheric venous 25(OH) D, calcium (Ca), magnesium (Mg), phosphor (P), alkaline phosphatase (ALP) and parathyroid hormone (PTH) of both groups were recorded. The sample size was estimated based on the effect size for a type I error of 5% and power of 80%.
Demographic characteristics of the two groups did not differ in terms of weekly physical activity levels and breast milk intake. The mean whole body BMI was similar in both groups of patients. History of previous fracture and 25(OH) D level were significantly lower in the patient group than the control group.
In the present study, the prevalence of vitamin D insufficiency or deficiency was higher in patients with forearm impaction type fractures than healthy controls and the baseline levels reported in the literature. In addition, there were no significant differences in serum Ca, Mg, P, ALP and PTH levels between the healthy controls and the patient group.
本研究旨在确定与健康对照组相比,桡骨远端嵌插骨折患儿25-羟基维生素D(25(OH)D)不足的患病率是否增加。
这是一项前瞻性对照研究。研究纳入了在骨科急诊诊所被诊断为前臂骨折的30名儿童,并将来自常规儿科门诊的30名健康儿童作为对照组。记录两组的外周静脉血25(OH)D、钙(Ca)、镁(Mg)、磷(P)、碱性磷酸酶(ALP)和甲状旁腺激素(PTH)水平。样本量根据5%的I型错误效应量和80%的检验效能进行估算。
两组在每周身体活动水平和母乳喂养摄入量方面的人口统计学特征无差异。两组患者的平均全身BMI相似。患者组既往骨折史和25(OH)D水平显著低于对照组。
在本研究中,前臂嵌插型骨折患者维生素D不足或缺乏的患病率高于健康对照组及文献报道的基线水平。此外,健康对照组与患者组之间血清Ca、Mg、P、ALP和PTH水平无显著差异。