Trulson M E, Cannon M S, Faegg T S, Raese J D
Brain Res Bull. 1987 Feb;18(2):269-77. doi: 10.1016/0361-9230(87)90201-2.
Long-term treatment of rats with methamphetamine (20 mg/kg, IP, every 12 hours for 10 days) resulted in a large decrease in tyrosine hydroxylase staining axons and terminal boutons in the nucleus accumbens and frontal cortex, as well as the ventral tegmental area of the midbrain, when examined 60 days following termination of the drug treatment regimen. Quantitative analysis showed a 71 and 78% decrease in tyrosine hydroxylase staining processes in the nucleus accumbens and frontal cortex, respectively, and a 90% decrease in tyrosine hydroxylase positive material in the ventral tegmental area. Thus, tyrosine hydroxylase enzyme in both the cell bodies of the midbrain ventral tegmental area as well as in the nerve terminals in post-synaptic target regions of the forebrain is depleted by chronic methamphetamine administration.
对大鼠长期给予甲基苯丙胺（20毫克/千克，腹腔注射，每12小时一次，持续10天），在药物治疗方案终止60天后进行检查时，伏隔核、额叶皮质以及中脑腹侧被盖区的酪氨酸羟化酶染色轴突和终末小体大幅减少。定量分析显示，伏隔核和额叶皮质中酪氨酸羟化酶染色过程分别减少了71%和78%，腹侧被盖区酪氨酸羟化酶阳性物质减少了90%。因此，慢性给予甲基苯丙胺会使中脑腹侧被盖区细胞体以及前脑突触后靶区域神经末梢中的酪氨酸羟化酶耗尽。
