Song Wen, Teng Wenhui, Shi Xinyan, Liu Xiaozhen, Cui Zheng, Tian Zibin
Gastrointestinal Endoscopy Center, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, PR China.
Operation Room, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, PR China.
Iran J Public Health. 2017 Jun;46(6):762-770.
The aim of this study was to explore the relationship between nutritional status and expression of RUNX3 in gastric cancer cells and to investigate the effects of nursing strategies on the nutritional status of elderly patients with advanced gastric cancer.
Forty-eight elderly patients admitted at Affiliated Hospital of Qingdao University with advanced gastric cancer and 30 healthy controls were selected as subjects from 2014-15. The correlation between RNX3 gene expression and nutritional status of the gastric cancer patients was investigated. The patients with advanced gastric cancer who had low expression of RUNX3 gene were treated with holistic nursing while routine nursing was taken for those patients who had normal or high expression of RUNX3 gene. The nutritional statuses of these patients were evaluated after 3 months of nursing. After a follow-up of 1 year, the influence of different nursing methods on the survival time was evaluated.
Compared with normal gastric tissue, the expression of RUNX3 gene and protein in tissues of advanced gastric cancer were significantly decreased (<0.01). Compared with patients with normal or high expressions of RUNX3, the nutritional statuses of advanced gastric cancer patients with low expressions of RUNX3 were lower (<0.01). The nutritional statuses of patients with low expressions of RUNX3 were notably improved after holistic nursing, becoming equivalent to those with normal or high expression of RUNX3 who received routine nursing (>0.05). The survival time of patients with low expression of RUNX3 who received holistic nursing were similar to patients with normal or high expression of RUNX3 who received routine nursing (>0.05).
RUNX3 is correlated with the occurrence and development of advanced gastric cancer. The low nutritional status of elderly advanced gastric cancer patients with low expressions of RUNX3 can be significantly enhanced by holistic nursing, thereby prolonging survival time.
本研究旨在探讨胃癌细胞中营养状况与RUNX3表达之间的关系，并研究护理策略对老年晚期胃癌患者营养状况的影响。
选取2014年至2015年期间在青岛大学附属医院收治的48例老年晚期胃癌患者和30例健康对照者作为研究对象。研究胃癌患者RNX3基因表达与营养状况之间的相关性。对RUNX3基因低表达的老年晚期胃癌患者采用整体护理，对RUNX3基因正常或高表达的患者采用常规护理。护理3个月后评估这些患者的营养状况。随访1年后，评估不同护理方法对生存时间的影响。
与正常胃组织相比，晚期胃癌组织中RUNX3基因和蛋白的表达明显降低（<0.01）。与RUNX3正常或高表达的患者相比，RUNX3低表达的晚期胃癌患者营养状况较差（<0.01）。整体护理后，RUNX3低表达患者的营养状况明显改善，与接受常规护理的RUNX3正常或高表达患者相当（>0.05）。接受整体护理的RUNX3低表达患者的生存时间与接受常规护理的RUNX3正常或高表达患者相似（>0.05）。
RUNX3与晚期胃癌的发生发展相关。整体护理可显著改善RUNX3低表达的老年晚期胃癌患者的低营养状况，从而延长生存时间。
