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靛红、3-氨基-1-苯基-2-吡唑啉-5-酮（3-氨基-1H-吡唑）和β-二酮在水相介质中的高效绿色反应。

An efficient and green reaction of isatins, 3-amino-1-phenyl-2-pyrazolin-5-one (3-amine-1H-pyrazole), and β-diketone in aqueous medium.

机构信息

Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou, 221116, Jiangsu, People's Republic of China.

出版信息

Mol Divers. 2017 Nov;21(4):985-997. doi: 10.1007/s11030-017-9780-5. Epub 2017 Aug 21.

DOI:10.1007/s11030-017-9780-5
PMID:28828682
Abstract

An efficient and green reaction of isatins, 3-amino-1-phenyl-2-pyrazolin-5-one (3-amine-1H-pyrazole), and [Formula: see text]-diketone in aqueous medium in the presence of [Formula: see text]-[Formula: see text] is reported, and a series of novel spirocompounds was obtained with high yields. The advantages of this reaction were simple procedure, moderate reaction conditions, and wide range of substrates. More importantly, the catalyst [Formula: see text]-[Formula: see text] could be recovered for reuse up to five times.

摘要

报道了一种在水介质中，在[Formula: see text]-[Formula: see text]存在下，通过靛红、3-氨基-1-苯基-2-吡唑啉-5-酮（3-氨基-1H-吡唑）和[Formula: see text]-二酮的高效、绿色反应，以高产率得到了一系列新型螺环化合物。该反应的优点是操作简单、反应条件温和、底物适用范围广。更重要的是，催化剂[Formula: see text]-[Formula: see text]可以回收并重复使用多达 5 次。

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