Department of Pediatric Radiology, Diyarbakır Children's Hospital, 21100, Diyarbakir, Turkey.
Department of Pediatric Endocrinology, Diyarbakır Children's Hospital, 21100, Diyarbakir, Turkey.
Radiol Med. 2017 Dec;122(12):960-966. doi: 10.1007/s11547-017-0801-3. Epub 2017 Aug 21.
This study aimed to evaluate the efficacy of Elastographic Strain Index (SI) in the diagnosis and grading of pediatric Hashimoto's thyroiditis (HT) patients.
This cross-sectional, controlled trial was carried out in the pediatric radiology department of our tertiary care center. The study group consisted of 63 children with HT and control group was composed of 47 healthy children. Conventional ultrasonography (US) and SI elastography measurements were performed through the Aplio™ 500 ultrasonic device with a linear 4.8-11.0 MHz transducer and elastography software. Furthermore, the correlation between strain ratio values and other variables was investigated.
The mean age of the HT patients was 139.63 ± 27.61 months, and no significant difference was found between the control group (143.09 ± 27.32 months) and the patients regarding mean age and gender. The mean SI of normal healthy individuals and patients with HT was 0.26 ± 0.77 and 1.75 ± 1.46, respectively (p < 0.001). For the diagnosis for HT with elastography, the sensitivity was 92.1%, and specificity was 66% when the optimal mean SI cut-off value was taken as 0.31, (p < 0.001).
The use of elastographic SI in patients with HT is a highly promising method for objective and countable results compared with the conventional US. The sensitivity of the increase in SI value was determined to be high in the diagnosis of HT. It was also considered that the elastography SI value had higher sensitivity and specificity than the conventional US in HT patients with moderate to advanced tissue hardening.
本研究旨在评估弹性应变指数（SI）在诊断和分级儿童桥本甲状腺炎（HT）患者中的作用。
这是一项在我们的三级护理中心儿科放射科进行的横断面、对照试验。研究组由 63 名 HT 患儿组成，对照组由 47 名健康儿童组成。通过 Aplio™500 超声设备和弹性成像软件进行常规超声（US）和 SI 弹性测量，该设备配备了一个 4.8-11.0MHz 的线性探头。此外，还研究了应变比值与其他变量之间的相关性。
HT 患儿的平均年龄为 139.63±27.61 个月，与对照组（143.09±27.32 个月）相比，平均年龄和性别无显著差异。正常健康个体和 HT 患者的平均 SI 分别为 0.26±0.77 和 1.75±1.46（p<0.001）。对于使用弹性成像诊断 HT，当最佳平均 SI 截断值为 0.31 时，其诊断 HT 的敏感性为 92.1%，特异性为 66%（p<0.001）。
与常规 US 相比，在 HT 患者中使用弹性 SI 是一种非常有前途的客观、可计数的方法。SI 值增加的敏感性被确定为 HT 诊断的高敏感性。还认为，在中重度组织硬化的 HT 患者中，弹性成像 SI 值的敏感性和特异性均高于常规 US。
