Cepeha Cristina Mihaela, Paul Corina, Borlea Andreea, Fofiu Renata, Borcan Florin, Dehelean Cristina Adriana, Ivan Viviana, Stoian Dana
PhD School Department, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Department of Internal Medicine II, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Diagnostics (Basel). 2021 Feb 5;11(2):248. doi: 10.3390/diagnostics11020248.
Chronic autoimmune thyroiditis (CAT) is the most common thyroid disorder in the pediatric population. Ultrasound evaluation may suggest the diagnosis. Additionally, shear-wave elastography (SWE) proved to be a valuable additional diagnosis tool in adults with CAT by assessing thyroid stiffness (TS). This study aims to assess its use also in detecting children with CAT. The study group consisted of 50 children with confirmed diagnosis of CAT, who were compared to the control group, consisting of 50 children with no thyroid pathology and with an adult group of 50 subjects with CAT. The evaluation included, besides bioimmunochemical evaluation, also thyroid ultrasound evaluation and elastography measurements in the same session (Aixplorer Mach 30, Supersonic imagine, France). The mean TS values were significantly lower for children in the CAT group compared to adults with CAT (15.51 ± 4.76 kPa vs. 20.96 ± 6.31 kPa; < 0.0001) and higher compared to the healthy aged matched controls (15.51 ± 4.76 kPa vs. 10.41 ± 2.01 kPa; < 0.0001). SWE elastography definitely seems a promising technique in the evaluation of children with autoimmune thyroid pathology.
慢性自身免疫性甲状腺炎(CAT)是儿科人群中最常见的甲状腺疾病。超声评估可能提示诊断。此外,剪切波弹性成像(SWE)通过评估甲状腺硬度(TS),已被证明是诊断成人CAT的一种有价值的辅助诊断工具。本研究旨在评估其在检测儿童CAT中的应用。研究组由50名确诊为CAT的儿童组成,与对照组进行比较,对照组由50名无甲状腺病变的儿童以及50名患有CAT的成人组成。评估除了生物免疫化学评估外,还在同一时段进行甲状腺超声评估和弹性成像测量(Aixplorer Mach 30,法国Supersonic imagine公司)。与患有CAT的成人相比,CAT组儿童的平均TS值显著更低(15.51±4.76 kPa vs. 20.96±6.31 kPa;<0.0001),与年龄匹配的健康对照组相比则更高(15.51±4.76 kPa vs. 10.41±2.01 kPa;<0.0001)。SWE弹性成像在评估患有自身免疫性甲状腺疾病的儿童方面无疑似乎是一项很有前景的技术。